Production

Our plant occupies an area of about 10.000 m2 of which about 6.000 are covered, while we own a neighbouring area of about 70.000 m2 available for a future expansion.

Production is structured on a 4-shift continuous cycle, 24 hours a day and 7 days a week.

All our departments are equipped with enamelled or AISI 316 stainless steel reactors having volume ranging between 2.500 to 12.000 liters.

CHENODEOXYCHOLIC ACID PHARMACEUTICAL GRADE

3α, 7α dihydroxy-5β-cholan-24-oic acid

Empirical Formula : C24 H40O4

Molecular Weight : 392.56

C.A.S. R.N. 474 – 25 – 9

Chenodeoxycholic acid is a natural substance found in human bile. It’s used in the treatment of gall stones disease and it’s obtained by synthesis starting from Cholic acid.


Quality : EP ( Pharma grade )

Packaging : 10 Kg fiber drum in a thermo coupled aluminium LDPE bag with drying agent Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place

CHENODEOXYCHOLIC ACID SODIUM SALT

3α, 7α dihydroxy-5β-cholan-24-oic sodium salt

Empirical Formula : C24 H39O4 Na

Molecular Weight : 414.56

C.A.S. R.N. 2646– 38 – 0

It has been the same pharmacological properties of Chenodeoxycholic acid.
It reduces cholesterol amount, probably by inhibiting liver synthesis, allowing gallstones dissolution.


Quality : PCA

DMF : Available under request

Packaging : Lab or pilot scale scale product.
Package available on customer demand

Storage conditions : Store in a tightly closed container in a cool and dry place.

CHOLIC ACID PHARMACEUTICAL GRADE

3α, 7α, 12α, trihydroxy-5β-cholan-24-oic acid

Empirical Formula : C24 H40O5

Molecular Weight : 408.56

C.A.S. R.N. 81 – 25 – 4

Cholic acid has been detected in the bile of most vertebrates in conjugation with glycine and taurine. It’s one of the end product of cholesterol metabolism.
We supply Cholic Acid "Pharmaceutical Grade".


Quality : PCA

DMF : Available EU (Pharma grade)

CEP : BSE/TSE minimization risk

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place

DEHYDROCHOLIC ACID

3, 7,12 trioxo-cholan-24-oic acid

Empirical Formula : C24 H34 O5

Molecular Weight : 402.53

C.A.S. R.N. 81 – 23 – 2

Dehydrocholic acid is a bile acid obtained by oxidation of hydroxyl groups in position 3, 7 and 12. and it’s used to increase the volume and the water content of the bile to improve biliary drainage.


Quality : USP / JP

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place

DEOXYCHOLIC ACID

3α, 12α, dihydroxy-5β-cholan-24-oic acid

Empirical Formula : C24 H40O4

Molecular Weight : 392.56

C.A.S. R.N. 82 – 44 – 3

Deoxycholic acid is a natural substance found in the intestine as secondary biliary obtained by an enzymatic process from Cholic acid.
It’s mainly used in the preparation of steroids.
It’s extracted from bovine bile where is found conjugated with Taurine and Glycine.
Its acts as a detergent to dissolve fats improving their absorption in intestine and it’s used as a choleretic detergent.
In some countries it was formerly licensed and used as a food additives.
It’s listed as a GRAS ( Generally Recognized As Safe) substance by FDA.


Quality : PCA

DMF : Available EU

CEP : Available (BSE/TSE minimization risk).

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place

DIHYDROXYPROPYLTHEOPHYLLINE

7-(2,3 dihydroxypropil)-theophylline or diprophylline.

Empirical Formula : C10 H14N4 O4

Molecular Weight : 254,20

C.A.S. R.N. 479 – 18 – 5

It’s a theophylline derivative having vasodilator and bronchodilator activities.
Respiratory smooth muscle relaxant actions are well known.


Quality : PCA

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place.

GLICODEOXYCHOLIC ACID SODIUM SALT

3α, 12α, Dihydroxy-5β-cholan-24- oic acid N-(carboxymethyl)amide sodium salt

Empirical Formula : C26 H42NO5 Na

Molecular Weight : 471.60

C.A.S. R.N. 16409 – 34– 0

It’s commonly used as detergent.

Quality : PCA

DMF : Available under request

Packaging : Lab or pilot scale scale product.
Package available on customer demand

Storage conditions : Store in a tightly closed container in a cool and dry place.

GLYCOCHOLIC ACID

3α, 7α, 12α, trihydroxy-5β-cholan-24- oic acid N-(carboxymethyl)amide

Empirical Formula : C26 H43NO6

Molecular Weight : 465.60

C.A.S. R.N. 475 – 31 – 0

It’s the main component of human bile and it’s obtained by synthesis starting from Cholic acid. Mainly used as biological enhancer, solubility agent and drug carrier.
It’s listed as a GRAS ( Generally Recognized As Safe) substance by FDA.


Quality : PCA

DMF : Available (US)

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.

Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place.

GLICOCHOLIC ACID SODIUM SALT

3α, 7α, 12α, trihydroxy-5β-cholan-24- oic acid N-(carboxymethyl)amide sodium salt

Empirical Formula : C26 H42NO6 Na

Molecular Weight : 487.60

C.A.S. R.N. 863–730 – 9

It’s used as a detergent and in the preparation of microbiological media.
It’s used as a water soluble form of Glycocholic acid.


Quality : PCA

DMF : Available under request

Packaging : Lab or pilot scale product.
Package available on customer demand


Storage conditions : Store in a tightly closed container in a cool and dry place.

GLYCOURSODEOXYCHOLIC ACID

3α, 7α dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide.

Empirical Formula : C26 H43NO5

Molecular Weight : 449.63

C.A.S. R.N. 64480 – 66 – 6

It’s the product of the conjugation between Ursodeoxycholic acid and Glycine. It ‘s a secondary bile acids obtained by enzymatic process by intestine microbial flora.
Recently clinical study has been run using glycoursodeoxycholic acid and interleukin-10 to modulate inflammatory state due to the accumulation of unconjugated bilirubin within brain and resulting in bilirubine encephalopathy.


Quality : PCA

DMF : Available under request

Packaging : Lab or pilot scale product.
Package available on customer demand


Storage conditions : Store in a tightly closed container in a cool and dry place.

LITHOCHOLIC ACID

3α, hydroxy-5β-cholan-24-oic acid

Empirical Formula : C24 H40O3

Molecular Weight : 376.56

C.A.S. R.N. 434 – 13 – 9

Lithocholic acid it’s a bile acid that acts as a detergent to dissolve fats and improve their absorption.
It’s under study as a biomarker of intra-hepatic cholestasis of pregnancy during Ursodeoxycholic acid treatment.


Quality : PCA

DMF : Available under request – technical package available.


Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

NATURAL TAURINE

2 amino ethane sulfonic acid

Empirical Formula : C2 H7NO3 S

Molecular Weight : 125.14

C.A.S. R.N. 107 – 35 – 7

Taurine is a natural amino acid widely found free and conjugated in animals tissue but pratically absent in vegetal world.
It’s extracted from mother liquor of bovine bile hydrolysis and it’s used as additive in milk for babies, health drinks and for cardiovascular and metabolic disorders.


Quality : JP , USP

DMF : Available under request – Technical package available

Packaging : 20 Kg in a thermo coupled aluminium LDPE bag with drying agent
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place.

SODIUM CHOLATE

3α, 7α, 12α, trihydroxy-5β-cholan-24-oic sodium salt

Empirical Formula : C24 H39O5 Na

Molecular Weight : 430.55

C.A.S. R.N. 361 – 09 – 1

It’s obtained from Cholic Acid.
It has been used to prevent gallstones generation and generally as drug carrier.
It has been used in the preparation and formulation of microbiological media.
Non ionic detergent is also used to extract membrane proteins.


Quality : PCA

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

SODIUM DEOXYCHOLATE

3α, 12α, dihydroxy-5β-cholan-24- sodium salt

Empirical Formula : C24 H39O4 Na

Molecular Weight : 414.55

C.A.S. R.N. 302 – 95 – 4

It’s obtained from Deoxycholic Acid.
It’s used as an anionic detergent in the extraction of the membrane receptors and to isolate proteic ions.
It’s also used in the preparation of microbiological media.
Recently appeared studies refer about its using in local fat reduction associated with phosphatidylcholine.


Quality : PCA

CEP : Available BSE/TSE minimization risk

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

TAUROCHOLIC ACID SODIUM SALT

3α, 7α, 12α trihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt

Empirical Formula : C26 H44NO7 S Na

Molecular Weight : 537.70

C.A.S. R.N. 145 – 42 – 6

It’s the sodium salt form of the conjugation between Taurine and Cholic acid and it’s naturally found in almost all mammal animals.
It’s used as a biological enhancer, solubilization agent and drug carrier.


Quality : PCA

DMF : Available under request – technical package available.

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

TAURODEOXYCHOLIC ACID SODIUM SALT

3α, 12α dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt

Empirical Formula : C26 H44NO6 S Na

Molecular Weight : 521.70

C.A.S. R.N. 1180 – 95 – 6

It’s the sodium salt form of the conjugation between Taurine and Deoxyholic acid.
It’s a biological and very efficacious detergent.
It’s used as a vehicle to support drug or vaccines delivery.


Quality : PCA
DMF : Available under request – technical package available.

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

TAUROURSODEOXYCHOLIC ACID SODIUM SALT

3α, 7β dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt

Empirical Formula : C26 H43NO6S Na

Molecular Weight : 521,70

C.A.S. R.N. 35807 – 85 – 3

It has detergent property.
Literature reports about its action in inhibiting human cholangiocarcinoma growth.


Quality : PCA

DMF : Available under request

Packaging : Lab or pilot scale scale product.
Package available on customer demand


Storage conditions : Store in a tightly closed container in a cool and dry place.

TAUROURSODEOXYCHOLIC ACID

3α, 7β dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide

Empirical Formula : C26 H44NO6S

Molecular Weight : 499.70

C.A.S. R.N. 14605 – 22 – 2

Tauroursodeoxycholic acid is obtained conjugating Ursodeoxycholic acid and Taurine. It’s used for dissolving cholesterol radio lucent gallstones, for treating chronic liver diseases with cholestasis, for treating primary biliary cirrhosis and viral and alcoholic chronic hepatitis.
It inhibits mitochondrial associated apoptosis. In animal models reduce ER stress and restore glucose homeostasis.


Quality : PCA

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Store in a tightly closed container in a cool and dry place

THEOPHYLLINE 7 ACETIC ACID

Theophylline-7-acetic acid or Carboxymethyltheophylline

Empirical Formula : C9 H10N4 O4

Molecular Weight : 238,20

C.A.S. R.N. 652 – 37 – 9

It’s a theophylline derivative having similar pharmacological effect but with more specific bronchodilator activity.
It’s used as carrier in improving ambroxol blood levels.
Its salts as acephylline are used as anti-asthmatic.


Quality : PCA

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.


Storage conditions : Stor Store in a tightly closed container in a cool and dry place

URSODEOXYCHOLIC ACID or URSODIOL

3α, 7β dihydroxy-5β-cholan-24-oic acid

Empirical Formula : C24 H40 O4

Molecular Weight : 392.56

C.A.S. R.N. 128 – 13 – 2

Ursodeoxycholic acid is a hydrophilic bile acid that occurs naturally in bile. It’s obtained by synthesis starting from Cholic acid. Used to produce level of cholesterol in the bile and for dissolution of cholesterol, radio-lucent gallstones. Furthermore it shows therapeutic effect in cholestatic liver diseases, improvement in serum liver enzymes and in primary biliary cirrhosis.
In addition it’s efficacious in improving hepatic function, sclerosing cholangitis, cystic fibrosis and chronic hepatitis. Recently it has been demonstrated that UDCA is an antioxidant that suppresses oxidative, stress in liver and enterochytis cells.


Quality : EP, USP, JP, current edition

DMF: EU, USP, JP Available

CEP: Double ( Manufacturing and BSE/TSE minimization risk).

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place.

XANTHINOL NICOTINATE

7-[3-[N-(2 hydroxyethyl)-methyl amino]-2-hydrohypropyl] theophylline nicotinate

Empirical Formula : C19 H26O6 N6

Molecular Weight : 434,45

C.A.S. R.N. 437 – 74 – 1

Xantinol nicotinate contains the pharmacologically active component nicotinic acid combined with the basic theophylline derivative Xantinol.
Positive treatment results have been reported in the treatment of cerebral insufficiency and improving short and long term memory; it has trombolytic and hipotensive activity.
It has been historically used as vasodilator and to prevent circulatory disease.


Quality : PCA

DMF : Available EU

Packaging : 25, 50 Kg in fiber drum with a double PE inner bags.
Smaller package are available on customer demand.

Storage conditions : Store in a tightly closed container in a cool and dry place